Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
BACKGROUND Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed. This study aims to investigate the therapeutic efficacy of the selective endothelin-A receptor antagonist TBC3711 in monocrotaline-induced pulmonary hypertension i...
متن کاملTherapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.
BACKGROUND Pulmonary arterial hypertension (PAH) is characterized by dysregulated proliferation of pulmonary artery smooth muscle cells leading to (mal)adaptive vascular remodeling. In the systemic circulation, vascular injury is associated with downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and alterations in Ca(2+) homeostasis in vascular smooth muscle cells that stimulat...
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Pulmonary arterial hypertension (PAH) is characterized by progressive increases in vascular resistance and the remodeling of pulmonary arteries. The accumulation of inflammatory cells in the lung and elevated levels of inflammatory cytokines in the bloodstream suggest that inflammation may play a role in PAH. In this study, the benefits of induced pluripotent stem cells (iPSCs) and iPSC-conditi...
متن کاملTherapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension Running title: Hadri et al.; SERCA2a gene transfer in pulmonary arterial hypertension
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY; Cardiovascular Medicine Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Hôpital Antoine-Béclère, Clamart, France; INSERM U999, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France; Fundación Centro Nacional de Investigaciones Cardiovasculares, Carlos III (CNIC), Mad...
متن کاملDexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Pulmonary arterial hypertension (PAH) is associated with dysregulated bone morphogenetic protein receptor (BMPR)-II signaling and pulmonary vascular inflammation. We evaluated the effects of dexamethasone on monocrotaline (MCT)-induced PAH in rats for potential reversal of PAH at late time-points. Saline-treated control, MCT-exposed, MCT-exposed and dexamethasone-treated rats (5 mg·kg⁻¹·day⁻¹, ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.113.001585